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Novel and Anti‐Inflammatory Constituents of Garcinia subelliptica
Author(s) -
Weng JingRu,
Lin ChunNan,
Tsao LoTi,
Wang JihPyang
Publication year - 2003
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200204535
Subject(s) - chemistry , superoxide , stereochemistry , histamine , compound 48/80 , cytochalasin b , degranulation , inhibitory postsynaptic potential , biochemistry , pharmacology , enzyme , in vitro , receptor , biology , neuroscience
Four novel phloroglucinol derivatives, garcinielliptones A ( 1 ), B ( 2 ), C ( 3 ), D ( 4 ), a novel triterpenoid, garcinielliptone E ( 5 ), and three known compounds were isolated from the seeds of Garcinia subellipti ca. The structures, including relative configurations, were elucidated by means of spectroscopic data. Known compounds garsubellin A ( 6 ) and garcinielliptin oxide ( 7 ) showed potent inhibitory effects on the release of β ‐glucuronidase, and β ‐glucuronidase and histamine, respectively, from peritoneal mast cells stimulated with compound 48/80 in a concentration‐dependent manner with IC 50 values of 15.6±2.5, and 18.2±3.6 and 20.0±2.7 μ M , respectively. Compound 7 showed potent inhibitory effects on the release of β ‐glucuronidase and lysozyme from neutrophils stimulated with formyl‐Met‐Leu‐Phe(fMLP)/cytochalasin B (CB) in a concentration‐dependent manner with IC 50 values of 15.7±3.0 and 23.9±3.2 μ M , respectively. Compound 7 also showed potent inhibitory effect on superoxide formation from neutrophils stimulated with fMLP/CB also in a concentration‐dependent manner with an IC 50 value of 17.9±1.5 μ M .