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Drug Discovery by Combinatorial Chemistry—the Development of a Novel Method for the Rapid Synthesis of Single Compounds
Author(s) -
Terrett Nicholas K.,
Gardner Mark,
Gordon David W.,
Kobylecki Ryszard J.,
Steele John
Publication year - 1997
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.19970031204
Subject(s) - drug discovery , combinatorial chemistry , combinatorial synthesis , computer science , chemistry , process (computing) , biochemical engineering , nanotechnology , materials science , engineering , biochemistry , operating system
Through the advantages conferred in the speed of synthesis, combinatorial chemistry is making a significant impact on the process of drug discovery. The mix‐and‐split paradigm has been an effective method for the production of compound mixtures, although there is now a need for new, fast library approaches to generate well‐characterised single compounds. Having already demonstrated the successful preparation and application of library mixtures, we have now developed a novel combinatorial method for the production of single compounds.