Drug Discovery by Combinatorial Chemistry—the Development of a Novel Method for the Rapid Synthesis of Single Compounds | Zendy

Terrett Nicholas K. | Zendy; Gardner Mark | Zendy; Gordon David W. | Zendy; Kobylecki Ryszard J. | Zendy; Steele John | Zendy

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Drug Discovery by Combinatorial Chemistry—the Development of a Novel Method for the Rapid Synthesis of Single Compounds

Author(s) -

Terrett Nicholas K.,

Gardner Mark,

Gordon David W.,

Kobylecki Ryszard J.,

Steele John

Publication year - 1997

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.19970031204

Subject(s) - drug discovery , combinatorial chemistry , combinatorial synthesis , computer science , chemistry , process (computing) , biochemical engineering , nanotechnology , materials science , engineering , biochemistry , operating system

Through the advantages conferred in the speed of synthesis, combinatorial chemistry is making a significant impact on the process of drug discovery. The mix‐and‐split paradigm has been an effective method for the production of compound mixtures, although there is now a need for new, fast library approaches to generate well‐characterised single compounds. Having already demonstrated the successful preparation and application of library mixtures, we have now developed a novel combinatorial method for the production of single compounds.

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