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Design of Sequence‐Specific DNA‐Binding Ligands
Author(s) -
Nielsen Peter E.
Publication year - 1997
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.19970030404
Subject(s) - oligonucleotide , dna , sequence (biology) , nucleic acid , base pair , minor groove , modular design , computational biology , complementary sequences , chemistry , combinatorial chemistry , stereochemistry , biochemistry , biology , computer science , mathematics , statistics , operating system
Double‐stranded DNA can be viewed as a multifunctional, modular receptor that can be read sequence‐selectively in a digital way (base pair per base pair) by a complementary, similarly modular ligand. This principle has been exploited in several approaches to design sequence‐specific DNA‐binding ligands, such as triplex‐forming oligonucleotides, peptide nucleic acids and minor groove binding polyamides.