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Optical Detection and Manipulation of Single Molecules in Room‐Temperature Solutions
Author(s) -
Chiu Daniel T.,
Zare Richard N.
Publication year - 1997
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.19970030304
Subject(s) - focus (optics) , electric field , gaussian beam , photon , molecule , fluorescence , optics , gaussian , laser beams , volume (thermodynamics) , physics , materials science , laser , beam (structure) , optoelectronics , atomic physics , nanotechnology , quantum mechanics
With the tight focus of a gaussian laser beam, single molecules in solution at room temperature can be trapped and detected by observation of fluorescent photons. The focus defines an ultrasmall probe volume on the order of 1 femtoliter, and the electric field gradient associated with this focus enables an individual molecule to be trapped and manipulated.