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Studies Towards the Total Synthesis of Epothilones: Asymmetric Synthesis of the Key Fragments
Author(s) -
Schinzer Dieter,
Limberg Anja,
Böhm Oliver M.
Publication year - 1996
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.19960021121
Subject(s) - epothilones , total synthesis , key (lock) , chemistry , stereochemistry , computer science , operating system
Members of a new class of macrolide—the so‐called epothilones ( 1 )—showing a taxol‐like biological activity have recently been isolated. A convergent approach to 1 is presented, and the asymmetric syntheses of the three key intermediates 3, 4 , and 8 are reported.
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