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Metal‐Mediated Synthesis of Multidomain Ligands—A New Strategy for Metallosupramolecular Chemistry
Author(s) -
Constable Edwin C.,
Thompson Alexander M. W. Cargill,
Harveson Peter,
Macko Ludwig,
Zehnder Margareta
Publication year - 1995
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.19950010606
Subject(s) - chemistry , terpyridine , ether , ruthenium , nucleophile , metal , ligand (biochemistry) , stereochemistry , combinatorial chemistry , williamson ether synthesis , yield (engineering) , medicinal chemistry , organic chemistry , catalysis , materials science , biochemistry , receptor , metallurgy
The bridging ligand bis{4′‐(2,2′:6′,2″‐terpyridinyl)}ether ( 1 ) can be prepared in 69% yield from the reaction of 4′‐chloro‐2,2′:6′,2″‐terpyridine ( 3 ) with 2,2′:6′,2″‐terpyridin‐4′(1′ H )‐one ( 2 ) in Me 2 NCHO in the presence of KOH. More conveniently, complexes of 1 can be prepared in situ by the reaction of 2 with a ruthenium(II) complex of 3 in the presence of K 2 CO 3 . This methodology has been developed for the synthesis of a range of mono‐, di‐, tri‐ and hexanuclear complexes with a variety of Xtpy (Xtpy = 4′‐substituted 2,2′:6′,2″‐terpyridine) terminator ligands. The molecular structure of 1 ( a = 9.623(2), b = 11.241(1), c = 11.828(1) Å; space group P 1 ; α = 93.064(9), β = 107.072(14), γ = 99.088(14)°; Z = 2, R = 0.0450, R w = 0.0577) has been determined. The generality of the methodology may ultimately be limited by the sensitivity of the ether‐linkage in 1 to attack by nucleophiles.