Open AccessStability of bioactive bone graft substitutes exposed to different aging and sterilization conditions
Author(s) -
Charbonneau Cindy,
Vanier Francis,
Lefebvre LouisPhilippe
Publication year - 2020
Publication title -
international journal of ceramic engineering and science
Language(s) - English
Resource type - Journals
ISSN - 2578-3270
DOI - 10.1002/ces2.10047
Subject(s) - sterilization (economics) , bioactive glass , dissolution , accelerated aging , chemical engineering , hydrogen peroxide , materials science , humidity , porosity , chemistry , composite material , organic chemistry , physics , monetary economics , economics , foreign exchange market , thermodynamics , engineering , foreign exchange
Abstract Bioactive glasses have been used for many years as bone graft substitutes in orthopedic and dental applications as well as an additive in toothpastes, cosmetics, and cosmeceutical products. The interest of using bioactive glass comes from its ability to dissolve and release dissolution products that stimulate bone regeneration. Porous bioactive glass scaffolds that can provide structural support while bone is growing into the structure have generated interest. However, little data is available in the literature on the effect of environmental conditions or sterilization treatments on the structure and properties of these materials. This study presents the evolution of the structure and microstructure of bioactive foams exposed to different accelerated and real‐time aging conditions and sterilization treatments. The results indicate that the material is relatively stable. For example, different sterilization methods (steam, ethylene oxide, hydrogen peroxide, gamma‐rays) have limited effect on the structure and properties of the foams. However, carbonate species may form on the surface of the material when exposed to CO 2 and humidity. Some carbonates dissolve rapidly in water and may impact the pH of the solution. Adequate packaging should limit the reaction of the bioactive glass with CO 2 and humidity and the formation of carbonate.