The Nenitzescu reaction: an initial screening of experimental conditions for improvment of the yield of a model reaction
Author(s) -
Katkevica Daze,
Trapencieris Peteris,
Boman Arne,
Kalvins Ivars,
Lundstedt Torbjörn
Publication year - 2004
Publication title -
journal of chemometrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.47
H-Index - 92
eISSN - 1099-128X
pISSN - 0886-9383
DOI - 10.1002/cem.863
Subject(s) - yield (engineering) , scope (computer science) , substrate (aquarium) , chemistry , reaction conditions , indole test , reaction rate , combinatorial chemistry , biochemical engineering , computer science , thermodynamics , organic chemistry , engineering , catalysis , physics , oceanography , programming language , geology
Abstract This paper describes the synthesis of the biologically important indole scaffold by using the Nenitzescu reaction. The scope and limitation of the reaction is investigated by multivariate methods where concentration, ratio of substrate and reactant, solvent, temperature and time are varied in a systematic way. The present investigation is the first reported systematic study of the impact of the experimental settings in the Nenitzescu reaction and is part of a more thorough project in which this reaction will be explored in more detail. Copyright © 2004 John Wiley & Sons, Ltd.