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In‐line analysis of a fluid bed pellet coating process using a combination of near infrared and Raman spectroscopy
Author(s) -
Bogomolov Andrey,
Engler Maximiliane,
Melichar Michael,
Wigmore Anthony
Publication year - 2010
Publication title -
journal of chemometrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.47
H-Index - 92
eISSN - 1099-128X
pISSN - 0886-9383
DOI - 10.1002/cem.1329
Subject(s) - raman spectroscopy , coating , pellet , chemometrics , process analytical technology , near infrared spectroscopy , process engineering , analytical chemistry (journal) , process (computing) , materials science , chemistry , chromatography , computer science , nanotechnology , optics , chemical engineering , composite material , engineering , bioprocess , operating system , physics
Near infrared (NIR) and Raman spectroscopic analyzers applied through an immersion Lighthouse Probe (LHP) were used for simultaneous in‐line monitoring of a fluid bed pellet coating process. Multivariate curve resolution analysis of data, collected from four pilot‐scale batches, has shown that the two techniques deliver complementary information about the process and their combination may be synergistic. This data analysis enabled a much better understanding of some of the process observations and also gave some interesting insights into the best way to use the techniques themselves. PLS regression analysis of the product moisture and the quantity of coating material sprayed was performed using NIR and Raman data blocks both separately and in combination. The performance of method combination compared to individual techniques is analyzed and discussed. Copyright © 2010 John Wiley & Sons, Ltd.