Premium
Detection and 2D Imaging of Dopamine Distribution Using a Closed Bipolar Electrode System by Applying a Cathodic Luminophore
Author(s) -
Iwama Tomoki,
Komatsu Mayo,
Inoue Kumi Y.,
Shiku Hitoshi
Publication year - 2021
Publication title -
chemelectrochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.182
H-Index - 59
ISSN - 2196-0216
DOI - 10.1002/celc.202100675
Subject(s) - luminophore , electrochemiluminescence , electrode , redox , chemistry , electrochemistry , dopamine , analytical chemistry (journal) , materials science , inorganic chemistry , optoelectronics , luminescence , chromatography , neuroscience , biology
A 2D imaging system using closed bipolar electrodes (cBPEs) and electrochemiluminescence (ECL) is expected to realize high spatio‐temporal resolution imaging. However, imaging of the distributions of molecules that cause an oxidation reaction on the electrode surface was not achieved by the cBPE/ECL system because the conventionally used luminophore can generate ECL only by an oxidation reaction. In this paper, we propose to implement a cathodic luminophore, [Ru(bpy) 3 ]Cl 2 /glutathione disulfide (GSSG) producing ECL by reduction reaction into the cBPE/ECL system to enable detection and 2D imaging of dopamine, which is an oxidizable redox species and an important neurotransmitter. The applicability of [Ru(bpy) 3 ]Cl 2 /GSSG for dopamine detection using a single cBPE was shown and its electrochemical properties were discussed. In addition, the demonstration of the 2D imaging of dopamine was performed using a cBPE array. These results show the potential to greatly expand the applicability of detection and imaging systems using cBPE/ECL.