Premium
Interaction of Redox Probes and Ferrocene‐labelled Peptides with Lipid Bilayers Observed at Lipid Bilayer‐Modified Electrodes
Author(s) -
Segan Dejan,
Stanley George,
Messina Pierluca,
Swiecicki JeanMarie,
Ngo Kieu,
Vivier Vincent,
Buriez Olivier,
Labbé Eric
Publication year - 2021
Publication title -
chemelectrochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.182
H-Index - 59
ISSN - 2196-0216
DOI - 10.1002/celc.202100501
Subject(s) - ferrocene , chemistry , redox , lipid bilayer , bilayer , phospholipid , membrane , electrochemistry , glassy carbon , cyclic voltammetry , electrode , inorganic chemistry , biochemistry
Glassy carbon electrodes (GCE) modified by a bilayer of phospholipids (BLM) have been used to monitor the passage of redox probes and ferrocene‐labelled peptides across lipid membranes of an anionic (DOPG) or a zwitterionic (globally neutral DPhPC) phospholipid. The gel‐phase neutral DPhPC showed a strong association with neutral probes like ferrocene methanol but expelled positively or negatively charged species, as observed on cyclic voltammograms. Anionic DOPG underwent a strong electrostatic interaction with the positively charged hexaamine ruthenium(III) complex, leading to aggregates that caused swelling and destructuration of the BLM. With positively charged ferrocene‐tagged peptides, DOPG‐modified GCE allowed the observation of cyclic voltammograms exhibiting both a potential shift with respect to bare GCE and increased peak intensity, accounting for the slow but favored partition of the peptides between the BLM and the solution.