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Chiral Biobased Ionic Liquids with Cations or Anions including Bile Acid Building Blocks as Chiral Selectors in Voltammetry
Author(s) -
Grecchi Sara,
Ferdeghini Claudio,
Longhi Mariangela,
Mezzetta Andrea,
Guazzelli Lorenzo,
Khawthong Siriwat,
Arduini Fabiana,
Chiappe Cinzia,
Iuliano Anna,
Mussini Patrizia Romana
Publication year - 2021
Publication title -
chemelectrochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.182
H-Index - 59
ISSN - 2196-0216
DOI - 10.1002/celc.202100200
Subject(s) - enantioselective synthesis , ionic liquid , enantiomer , deoxycholic acid , cyclic voltammetry , electrochemistry , combinatorial chemistry , materials science , chirality (physics) , chemistry , organic chemistry , electrode , bile acid , chiral anomaly , catalysis , physics , nambu–jona lasinio model , biochemistry , fermion , quantum mechanics
Chiral ionic liquids (CILs), or ionic liquids (ILs) with chiral additives, are very attractive chiral media for enantioselective electroanalysis, on account of their high chiral structural order at the electrochemical interphase. A family of molecular salts with CIL properties is now introduced, based on the chiral steroid building block of deoxycholic acid implemented either in the anion or cation. Testing them as chiral additives in a commercial achiral IL, they enable voltammetric discrimination of the enantiomers of a model chiral probe on disposable screen‐printed electrodes in terms of peak potential differences, which is the most desirable transduction mode of the enantiorecognition event. The probe enantiomer sequence is the same for all selectors, consistent with their sharing the same chiral building block configuration. This proof‐of‐concept widens the application fields of bile acid derivatives as chiral selectors, while also enriching the still very few CIL families so far explored for applications in chiral electroanalysis.