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Carbon Nanotube‐Based Molecularly Imprinted Voltammetric Sensor for Selective Diuretic Analysis of Dialysate and Hemodialysis Wastewater
Author(s) -
Oliveira Gabriela F.,
Hudari Felipe F.,
Pereira Fabíola M. V.,
Zai Maria V. B.,
Silva José L.
Publication year - 2020
Publication title -
chemelectrochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.182
H-Index - 59
ISSN - 2196-0216
DOI - 10.1002/celc.202000329
Subject(s) - carbon nanotube , molecularly imprinted polymer , detection limit , materials science , selectivity , electrochemistry , cyclic voltammetry , response surface methodology , chemical engineering , electrode , nuclear chemistry , electrochemical gas sensor , chromatography , nanotechnology , chemistry , organic chemistry , catalysis , engineering
A molecularly imprinted polymer (MIP)‐based electrochemical sensor was developed for the monitoring of hydrochlorothiazide (HCT) in dialysate and hemodialysis wastewater. The MIP was constructed by the electropolymerization of ortho‐phenylenediamine on multi‐walled carbon nanotube modified glassy carbon electrode surface. The experimental optimization was carried out by Plackett‐Burman design screening and central composite design. Through square wave voltammetry (SWV) analysis, the sensor presented linear response in the range of 5.0×10 −6 to 1.0×10 −4 mol L −1 ( R =0.9995) and detection limit of 3.2×10 −6 mol L −1 . The film morphology was investigated by SEM, EDX and AFM, and the electrochemical response was confirmed by EIS. The MIP film exhibited excellent selectivity for HCT, rapid response and good practicability. The sensor was successfully applied for direct and selective determination of HCT in dialysate and hemodialysis wastewater samples with recovery rates ranging from 97 % to 102 % based on the standard addition method.