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Microfluidic System with Extended‐Gate‐Type Organic Transistor for Real‐Time Glucose Monitoring
Author(s) -
Didier Pierre,
LobatoDauzier Nicolas,
Clément Nicolas,
Genot Anthony J.,
Sasaki Yui,
Leclerc Éric,
Minamiki Tsukuru,
Sakai Yasuyuki,
Fujii Teruo,
Minami Tsuyoshi
Publication year - 2020
Publication title -
chemelectrochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.182
H-Index - 59
ISSN - 2196-0216
DOI - 10.1002/celc.201902013
Subject(s) - microfluidics , organic field effect transistor , flexibility (engineering) , phenylboronic acid , transistor , materials science , continuous glucose monitoring , nanotechnology , biosensor , computer science , field effect transistor , chemistry , electrical engineering , engineering , catalysis , medicine , organic chemistry , statistics , mathematics , voltage , endocrinology , glycemic , insulin
Organic field‐effect transistors (OFETs) can be potentially employed to monitor cell activities for healthcare and medical treatment because of their attractive properties such as ease of use, flexibility, and low‐cost manufacturing processes. Although current OFET‐based sensors are suitable for point‐of‐care testing, the establishment of real‐time monitoring methods is in high demand for continuous monitoring of health conditions and/or biological cell activities. In this regard, we herein propose a microfluidic platform integrated with an extended‐gate‐type OFET for real‐time glucose monitoring. The mechanism of glucose detection depends on the artificial receptor phenylboronic acid and its boronate esterification. After optimization of the microfluidics for the OFET‐based sensor, the sensor was used to monitor glucose consumption and release in a model of pseudo‐liver cells. Random increases or decreases in the glucose concentration were reproducibly monitored.