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Hexafluoro‐2‐Propanol‐Promoted Electro‐Oxidative [3+2] Annulation of 1,3‐Dicarbonyl Compounds and Alkenes
Author(s) -
Xiong Mingteng,
Liang Xingan,
Liang Xiao,
Pan Yuanjiang,
Lei Aiwen
Publication year - 2019
Publication title -
chemelectrochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.182
H-Index - 59
ISSN - 2196-0216
DOI - 10.1002/celc.201900753
Subject(s) - annulation , dehydrogenation , chemistry , catalysis , oxidative phosphorylation , propanol , medicinal chemistry , organic chemistry , combinatorial chemistry , ethanol , biochemistry
Abstract : A straightforward and atom‐economical approach to the synthesis of dihydrofurans employing electro‐oxidative [3+2] annulation of 1,3‐dicarbonyl compound and alkenes has been developed. Neither metal catalysts nor chemical oxidants are required to promote the dehydrogenation process. Moreover, the use of base to decrease the oxidative potential and 1,1,1,3,3,3‐hexafluoro‐2‐propanol to stabilize the reactive intermediates are key to the success of the cyclization.