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Electrochemical Synthesis of 3‐Bromoimidazo[1,2‐a]pyridines Directly from 2‐Aminopyridines and alpha ‐Bromoketones
Author(s) -
Jian WenQian,
Wang HaiBin,
Du KeSi,
Zhong WeiQiang,
Huang JingMei
Publication year - 2019
Publication title -
chemelectrochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.182
H-Index - 59
ISSN - 2196-0216
DOI - 10.1002/celc.201900406
Subject(s) - aminopyridines , electrolysis , halogenation , electrochemistry , substrate (aquarium) , chemistry , combinatorial chemistry , condensation , domino , medicinal chemistry , organic chemistry , physics , electrode , catalysis , thermodynamics , oceanography , electrolyte , geology
A highly efficient co‐electrolysis of 3‐bromoimidazo[1,2‐a]pyridines has been developed in a simple undivided cell without any external oxidant. This protocol proceeds smoothly to provide the products with a broad substrate scope through a domino condensation/bromination sequence. Importantly, it can be easily scaled up.