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Metabolism‐Inspired Electrosynthesis
Author(s) -
Rahman Muhammad H.,
Bal Mandeep K.,
Jones Alan M.
Publication year - 2019
Publication title -
chemelectrochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.182
H-Index - 59
ISSN - 2196-0216
DOI - 10.1002/celc.201900117
Subject(s) - electrosynthesis , the renaissance , drug discovery , drug , drug metabolism , chemistry , nanotechnology , pharmacology , medicine , biochemistry , electrochemistry , materials science , electrode , art , art history
Drug metabolism is a critical stage in the development of new chemical entities to understand how the drug will behave in the body and to reveal potential toxic metabolites. In this Review, we discuss how a renaissance in the applications of synthetic electrochemistry can be employed both to identify drug metabolites (and mechanisms) and enable electrosynthetic preparation of drug metabolites for further analysis. Recent advances in electro‐oxidative drug reactions are reviewed together with a perspective on the future use of electrosynthesis to diversify lead stage drug molecules to enable rapid testing of advanced analogues. A focus on the remarkable advances in the last decade with the inclusion of seminal papers for contextual analysis are reviewed.