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Electrochemical Flash Fluorination and Radiofluorination
Author(s) -
Balandeh Mehrdad,
Rios Alejandra,
Allison Nathanael,
Shirazi Daniela,
Gomez Adrian,
Rambaran Laura,
Holloway Travis,
Sadeghi Saman
Publication year - 2018
Publication title -
chemelectrochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.182
H-Index - 59
ISSN - 2196-0216
DOI - 10.1002/celc.201800973
Subject(s) - electrochemistry , fluoride , electrolysis , carbocation , chemistry , solvent , flash (photography) , inorganic chemistry , organic chemistry , electrode , electrolyte , art , visual arts
A new method for rapid late‐stage fluorination using the cation pool technique is presented. Fluorination and no‐carrier‐added radiofluorination of methyl (phenylthio) acetate, methyl 2‐(methylthio) acetate, and methyl 2‐(ethylthio) acetate were performed. The carbocations formed through electrochemical oxidation were stabilized by using a divided electrochemical cell and 2,2,2‐trifluoroethanol (TFE) as the solvent at −20 °C. At the end of electrolysis, either stable‐isotope [ 19 F]fluoride or no‐carrier‐added radioactive [ 18 F]fluoride was added to the reaction mixture to form the fluorinated or radiofluorinated product.