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Progress of the Electrochemiluminescence Biosensing Strategy for Clinical Diagnosis with Luminol as the Sensing Probe
Author(s) -
Fang Chen,
Li Huiling,
Yan Jilin,
Guo Heming,
Yifeng Tu
Publication year - 2017
Publication title -
chemelectrochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.182
H-Index - 59
ISSN - 2196-0216
DOI - 10.1002/celc.201700465
Subject(s) - electrochemiluminescence , luminol , biosensor , luminophore , chemiluminescence , nanotechnology , nanomaterials , materials science , chemistry , electrode , optoelectronics , luminescence , chromatography
Electrochemiluminescence (electrogenerated chemiluminescence, ECL), which involves light emission from excited states of electrochemically generated species at the electrode surface, is widely applied for chemical analysis. Integrating the advantages of outstanding selectivity from biological recognition and the high sensitivity of ECL signaling, ECL biosensors are powerful for ultrasensitive bio‐checkups and quantification, in which luminol is adopted as an important luminophore. Nanomaterials have been introduced into ECL biosensors, which enlarge the applicable pH range and improve analytical performances, with successful applications in clinical events. In particular, this Minireview will focus on new progresses related to luminol‐based biosensors and their applications in clinical diagnosis, with emphasis on nanomaterials being employed as the improver.