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Measuring the Content of a Single Liposome through Electrocatalytic Nanoimpact “Titrations”
Author(s) -
Cheng Wei,
Compton Richard G.
Publication year - 2016
Publication title -
chemelectrochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.182
H-Index - 59
ISSN - 2196-0216
DOI - 10.1002/celc.201600396
Subject(s) - liposome , titration , glutathione , chemistry , redox , nanoparticle , electrode , electrochemistry , inorganic chemistry , combinatorial chemistry , nanotechnology , materials science , biochemistry , enzyme
We show the electrochemical determination of attomole glutathione contents within single individual liposomes at low overpotentials through mediated electron transfer by using copper (II) as a catalyst for the oxidation of liposomal glutathione. A “titration‐like” behaviour of individual liposomes was observed when impacting with the electrode to quantify the content within single liposomes. The nanoimpacts “titration” strategy allows the characterisation of nanoparticles containing redox‐inactive molecules at the single‐nanoparticle level.