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Bone‐Targeted Cisplatin‐Complexed Poly(γ‐benzyl‐ L ‐glutamate)–Poly(glutamic acid) Block Polymer Nanoparticles: An Electrochemical Approach
Author(s) -
de Miguel Laura,
CebriánTorrejón Gerardo,
Caudron Eric,
Arpinati Ludovica,
DoménechCarbó Antonio,
Ponchel Gilles
Publication year - 2015
Publication title -
chemelectrochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.182
H-Index - 59
ISSN - 2196-0216
DOI - 10.1002/celc.201402400
Subject(s) - ethylene glycol , copolymer , glutamic acid , cisplatin , glutamate receptor , nanoparticle , electrochemistry , polymer , polymer chemistry , chemistry , nuclear chemistry , materials science , amino acid , organic chemistry , biochemistry , nanotechnology , electrode , receptor , medicine , chemotherapy , surgery
The voltammetric response of different osteotropic multifunctional nanoparticles based on cisplatin‐complexed poly(γ‐benzyl‐ L ‐glutamate)–poly(glutamic acid) block polymer (CDDP‐PBLG‐ b ‐PGlu) copolymer, with or without poly(γ‐benzyl‐ L ‐glutamate)–poly(ethylene glycol) block polymer (PBLG‐ b ‐PEG), and having bone‐targeting properties is studied at biologically relevant pH. Significant differences in the cisplatin‐centered voltammetric signals allow monitoring of the association of cisplatin to nanoparticles as well as release kinetics from them, in agreement with atomic absorption spectroscopy data. Electrochemical studies reveal that the cisplatin association is significant only if the proportion of the PBLG‐ b ‐PGlu copolymer was greater than PBLG‐ b ‐PEG.