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Fundamental Properties of Phenylboronic‐Acid‐Coated Gate Field‐Effect Transistor for Saccharide Sensing
Author(s) -
Kajisa Taira,
Sakata Toshiya
Publication year - 2014
Publication title -
chemelectrochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.182
H-Index - 59
ISSN - 2196-0216
DOI - 10.1002/celc.201402193
Subject(s) - phenylboronic acid , monosaccharide , field effect transistor , chemistry , boronic acid , biosensor , transistor , substrate (aquarium) , nanotechnology , electrode , materials science , analytical chemistry (journal) , combinatorial chemistry , chromatography , voltage , organic chemistry , electrical engineering , oceanography , geology , engineering , catalysis
We report the surface and electrical characteristics of a phenylboronic acid (PBA)‐coated gate field effect transistor (FET) biosensor for a highly sensitive detection of various saccharides. 4‐mercaptophenylboronic acid (MPBA) was self‐assembled on a Au extended‐gate electrode, which was used as a saccharide recognition substrate of the PBA–FET. The binding affinity of PBA with various monosaccharides and disaccharides were evaluated by the amount of voltage changes on the Au gate surface in response to sugar concentrations using the PBA–FET. The specific diol‐binding of PBA with saccharides induces molecular charges onto PBA, resulting in the detection of charges at a lower concentration of 50 μ M . In particular, the binding affinities of PBA with the saccharides contributes to the different electrical signals. The platform based on the PBA–FET is useful for a convenient and highly sensitive detection of various saccharides in the fields of food engineering and medicine.