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Kinetic of a liquid/liquid/solid fine chemicals reactions – modelling of a continuous pilot plant reactor
Author(s) -
Chamayou Alain,
Delmas Henri,
Casamatta Gilbert
Publication year - 1996
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.270190111
Subject(s) - pilot plant , process (computing) , process engineering , batch reactor , mass transfer , scale up , work (physics) , kinetics , chemistry , limiting , liquid phase , thermodynamics , chromatography , engineering , computer science , organic chemistry , catalysis , mechanical engineering , physics , classical mechanics , quantum mechanics , operating system
In the field of fine chemicals batch process the implementation of synthesis paths results most often in the determination of the optimal operating conditions on a bench scale apparatus; successive scale‐ups are then handled in an empirical way. For multi‐phase reactions, this approach can be limited due to the coupling between the chemical kinetics and the physical kinetics of the mass transfer. This work proposes a more rational approach for the overall synthesis of Amiodarone, a widely used anti‐arrhythmic drug produced by a liquid/liquid/solid reaction. After analysing the reaction scheme and identifying the limiting steps of the process, a simplified model is proposed to describe the overall process kinetics. The latter is used to model a continuous pilot loop‐reactor packed with static mixers.