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Xanthan production in stirred tank fermenters: Oxygen transfer and scale‐up
Author(s) -
Herbst Holger,
Schumpe Adrian,
Deckwer WolfDieter
Publication year - 1992
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.270150610
Subject(s) - mass transfer , xanthomonas campestris , impeller , yield (engineering) , mass transfer coefficient , chemistry , viscosity , continuous stirred tank reactor , constant (computer programming) , xanthan gum , bioreactor , thermodynamics , chromatography , rheology , physics , organic chemistry , computer science , gene , programming language , biochemistry
The microbial polysaccharide xanthan was produced by cultivation of Xanthomonas campestris in four stirred tanks with volumes ranging from 0.072 to 3 m 3 . Many of the previously suggested correlations for the volumetric mass transfer coefficient described the present data very unsatisfactorily. When Rushton turbines were employed as stirrers, the experimental results agreed well with a correlation suggested by Kawase and Moo‐Young; for the more energy‐efficient INTERMIG impellers, this correlation was modified by a factor of three. Constant specific oxygen transfer rate was found to be the appropriate scale‐up criterion for constant space‐time yield and constant product quality, specifically, the molar mass which determines the viscosity yield.