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Isothermal by Design: Comparison with an Established Isothermal Nucleation Kinetics Analysis Method
Author(s) -
Kaskiewicz Peter L.,
Turner Thomas D.,
Warren Nicholas J.,
Morton Colin,
Dowding Peter J.,
George Neil,
Roberts Kevin J.
Publication year - 2020
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.202000113
Subject(s) - nucleation , supersaturation , isothermal process , thermodynamics , aqueous solution , chemistry , crystallization , kinetics , solvation , solvent , organic chemistry , physics , quantum mechanics
The nucleation kinetics of the alpha form of p ‐aminobenzoic acid from ethanolic and aqueous solutions is examined through a comparative examination of temperature‐jump and anti‐solvent drown‐out isothermal crystallization methodologies. Analysis of the data reveals the measured induction times, and the calculated effective interfacial tensions as a function of the supersaturation show broadly equivalent behavior for the aqueous‐ethanol mixed‐solvent drown‐out and temperature‐jump ethanol solution systems, confirming the comparability of the two methodologies. The results also demonstrate poorer agreement with the temperature‐jump pure aqueous system, highlighting the importance of the strength of solvation/desolvation as the key rate‐limiting process for the overall nucleation behavior.