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Resolution by Preferential Crystallization of Proxyphylline by Using Its Salicylic Acid Monohydrate Co‐Crystal
Author(s) -
Harfouche Lina C.,
Brandel Clément,
Cartigny Yohann,
Petit Samuel,
Coquerel Gérard
Publication year - 2020
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.202000040
Subject(s) - crystallization , salicylic acid , crystal (programming language) , mother liquor , chemistry , crystal growth , active ingredient , enantiomer , chemical engineering , crystallography , resolution (logic) , chiral resolution , organic chemistry , bioinformatics , biochemistry , computer science , artificial intelligence , biology , programming language , engineering
The monohydrated co‐crystal composed of the chiral active pharmaceutical ingredient proxyphylline, salicylic acid, and water was successfully resolved by preferential crystallization from a water/ethanol mixture. To the best of our knowledge, this is the first report of preferential crystallization applied to such a system and the results reveal that unusually high enantiomeric excess values can be attained in the mother liquor. These robust and reproducible results underline the potential of preferential crystallization to resolve co‐crystal systems.