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Solid Solubilities of Sulfonamides and Use of Rapid Expansion of Supercritical Solutions for Microparticle Production
Author(s) -
Yang Tsung-Mao,
Li Jin-Shuh,
Yeh Tsao-Fa,
Su Chie-Shaan
Publication year - 2020
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201900646
Subject(s) - solubility , supercritical fluid , chemistry , microparticle , extrapolation , hildebrand solubility parameter , thermodynamics , chromatography , chemical engineering , organic chemistry , mathematics , engineering , physics , mathematical analysis
The solubility of solid active pharmaceutical ingredients in supercritical fluids is a major thermodynamic criterion for selection and screening of microparticle generation processes. To develop an efficient method for solubility prediction, a solution model was adopted to establish the correlations of the solid solubilities of six sulfonamides in supercritical CO 2 . The model was capable of determining solubility correlations. Accordingly, it was attempted to simplify and generalize the model, yielding a predictive solution model, which provided order‐consistent solubility predictions. A case study for model extrapolation was conducted. After understanding the mechanisms underlying the solubility of sulfonamides, the rapid expansion of supercritical solutions (RESS) process was applied to produce microparticles of p ‐toluenesulfonamide, an anticancer drug. The effects of RESS process parameters were investigated.