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Partial Seeding Policy for Controlling the Crystal Quality in Batch Cooling Crystallization
Author(s) -
Unno Joi,
Hirasawa Izumi
Publication year - 2020
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201900618
Subject(s) - seeding , crystallization , seed crystal , slurry , crystal (programming language) , materials science , yield (engineering) , thermodynamics , crystallography , chemistry , single crystal , composite material , physics , computer science , programming language
Partial seeding, in which the nuclei originating from seed crystals grow to yield the product crystals, was simulated and optimized for controlling the batch cooling crystallization process of L ‐arginine. The product quality was evaluated by the coefficient of variation ( CV ) of the crystal size distribution. First, the optimum seed amount for partial seeding was estimated by simulation. Then, the simulated values of the optimum seed amount and the resulting local minimum CV were correlated with the seed crystal size and the cooling rate. The correlation can be utilized for estimating the seed amount in the case that the seed crystals are added in a slurry. Finally, these simulated values were compared to the measured ones. Consequently, the optimum seed amount was suggested to be reasonably predicted.