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Contact Behavior of Microcrystalline Cellulose Pellets Depending on their Water Content
Author(s) -
Grohn Philipp,
Weis Dominik,
Thommes Markus,
Heinrich Stefan,
Antonyuk Sergiy
Publication year - 2020
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201900517
Subject(s) - pellets , microcrystalline cellulose , materials science , breakage , pellet , composite material , water content , extrusion , deformation (meteorology) , cellulose , geotechnical engineering , chemical engineering , engineering
Microcrystalline cellulose pellets for oral drug delivery are often produced by a combined wet extrusion‐spheronization process. During the entire process, the cylindrical as well as the spherical pellets are exposed to various stresses resulting in a change of their shape and size due to plastic deformation and breakage. In this work, the effect of moisture content of pellets on their mechanical behavior is studied. In static compression tests, the strong influence of water content on deformation behavior of pellets is confirmed. Moreover, impact tests are performed using a setup consisting of three high‐speed cameras to record pellet‐wall collisions. Material properties, such as stiffness, restitution coefficient, breakage force, and displacement, were analyzed depending on the water content.