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Effect of Sodium Dodecyl Sulfate on the Continuous Crystallization in Microfluidic Devices Using Microbubbles
Author(s) -
Fatemi Naghmeh,
Devos Cedric,
Cordt Glenn,
Gerven Tom,
Kuhn Simon
Publication year - 2019
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201900172
Subject(s) - nucleation , crystallization , sodium dodecyl sulfate , chemical engineering , microfluidics , microreactor , materials science , microbubbles , chemistry , chromatography , nanotechnology , organic chemistry , ultrasound , catalysis , physics , acoustics , engineering
Introducing microbubbles in a microreactor for continuous crystallization increases the nucleation rate and also prevents clogging. Adding surfactants affects the microbubble generation as it reduces their size, increases their frequency of formation and consequently also the interfacial area per unit volume of reactor acting as heterogeneous surface for nucleation. Here, the effect of sodium dodecyl sulfate (SDS) on both the microbubble generation and the continuous crystallization of paracetamol is investigated. It is observed that while SDS significantly enlarges the heterogeneous surface available for nucleation, the crystallization itself is inhibited by its presence.