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Equipment and Separation Units for Flow Chemistry Applications and Process Development
Author(s) -
Bittorf Lukas,
Reichmann Felix,
Schmalenberg Mira,
Soboll Sebastian,
Kockmann Norbert
Publication year - 2019
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201900120
Subject(s) - microreactor , process engineering , flow chemistry , distillation , process (computing) , scale (ratio) , automation , flow (mathematics) , residence time (fluid dynamics) , dispersion (optics) , process development , mixing (physics) , microfluidics , chemistry , mechanical engineering , materials science , engineering , computer science , continuous flow , nanotechnology , mechanics , chromatography , biochemical engineering , physics , organic chemistry , catalysis , geotechnical engineering , optics , quantum mechanics , operating system
Process development and small‐scale production gets more and more important in fine chemistry and pharmaceutical production. An equipment toolbox assists process synthesis presented in this contribution. A microfluidic calorimeter can measure kinetic and thermodynamic reaction data with commercial plate reactors. A tubular reactor coiled with 90° bends allows for long residence time with low axial dispersion, also known as coiled flow inverter (CFI). A similar setup is used for continuous‐flow cooling crystallization. Small‐scale columns with rotating internals are employed for distillation and liquid‐liquid extraction. Main emphasis will be put on automation and scale‐up in future steps.