Premium
Gelatin‐Based Capsules through Interfacial Polymerization: Batch and Continuous Flow Synthesis
Author(s) -
Bacher Lisa,
Maskos Michael,
Musyanovych Anna
Publication year - 2019
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201900119
Subject(s) - gelatin , miniemulsion , materials science , polymerization , dynamic light scattering , fourier transform infrared spectroscopy , chemical engineering , sulforhodamine b , nanoparticle , polymer chemistry , chemistry , nanotechnology , organic chemistry , polymer , composite material , biochemistry , cytotoxicity , engineering , in vitro
Cross‐linked gelatin capsules were prepared through interfacial polymerization in the inverse miniemulsion, using toluene diisocyanate (TDI) as a cross‐linker. Synthesis was performed in a batch process and in a continuous flow using a static micromixer. The obtained capsules were in the size range between 0.5 and 2 µm. The influence of TDI amount, pH of gelatin solution, and flow rates on the properties of capsules was studied by dynamic light scattering, transmission electron microscopy, and Fourier transform infrared spectroscopy. The thermoresponsive release of the hydrophilic dye sulforhodamine 101 was investigated by fluorescent spectroscopy. Furthermore, gelatin capsules loaded with magnetite nanoparticles were synthesized in a continuous way, showing the potential to produce capsules for drug release triggered by magnetic hyperthermia in large quantities.