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Synthesis of the Antibiotic Precursor Thiazolyl‐7‐Aminocephalosporanic Acid in a Microstructured Flow System
Author(s) -
Wirth Vanessa,
Volkmar Julia,
Bayer Thomas
Publication year - 2019
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201900077
Subject(s) - yield (engineering) , combinatorial chemistry , flow chemistry , chemistry , antibiotics , chemical engineering , materials science , organic chemistry , catalysis , biochemistry , engineering , metallurgy
The synthesis of thiazolyl‐7‐aminocephalosporanic acid, a pharmaceutical precursor of the β ‐lactam antibiotic drug cefodizime, could be successfully realized in a continuous microstructured flow system. This was accomplished by changing the process window from batch, having a reaction temperature of 60 °C with a reaction time of 1 h, to a flow system at temperatures > 100 °C and reaction times of several minutes. The space‐time yield could be increased by a factor of 130.