Synthesis of the Antibiotic Precursor Thiazolyl‐7‐Aminocephalosporanic Acid in a Microstructured Flow System | Zendy

Wirth Vanessa | Zendy; Volkmar Julia | Zendy; Bayer Thomas | Zendy

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Synthesis of the Antibiotic Precursor Thiazolyl‐7‐Aminocephalosporanic Acid in a Microstructured Flow System

Author(s) -

Wirth Vanessa,

Volkmar Julia,

Bayer Thomas

Publication year - 2019

Publication title -

chemical engineering and technology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.403

H-Index - 81

eISSN - 1521-4125

pISSN - 0930-7516

DOI - 10.1002/ceat.201900077

Subject(s) - yield (engineering) , combinatorial chemistry , flow chemistry , chemistry , antibiotics , chemical engineering , materials science , organic chemistry , catalysis , biochemistry , engineering , metallurgy

The synthesis of thiazolyl‐7‐aminocephalosporanic acid, a pharmaceutical precursor of the β ‐lactam antibiotic drug cefodizime, could be successfully realized in a continuous microstructured flow system. This was accomplished by changing the process window from batch, having a reaction temperature of 60 °C with a reaction time of 1 h, to a flow system at temperatures > 100 °C and reaction times of several minutes. The space‐time yield could be increased by a factor of 130.

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