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Influence of the Solvent Content on the Phase Transformation of Sulfadiazine N ‐Methyl Pyrrolidone Solvate
Author(s) -
Macaringue Estevao G. J.,
Wu Songgu,
Liu Shiyuan,
Xu Shijie,
Gong Junbo
Publication year - 2019
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201800738
Subject(s) - solvent , chemistry , raman spectroscopy , solubility , phase (matter) , scanning electron microscope , molecule , transformation (genetics) , solvent effects , crystallography , chemical engineering , analytical chemistry (journal) , organic chemistry , materials science , optics , biochemistry , physics , composite material , gene , engineering
The influence of the solvent content on the solution‐mediated phase transformation of sulfadiazine (SD) N ‐methyl pyrrolidone (NMP) solvate into SD was investigated for process development. The solubility results of the NMP solvate and SD in NMP solvent/water mixtures supported by the analysis of solvent‐solvent interactions between NMP solvent molecules were used to understand and optimize the transformation of the NMP solvate into SD. Needle‐on‐rhombic‐like aggregated crystals and rod‐like single crystals of SD were obtained and reported for the first time. By combining Raman spectroscopy, focused‐beam reflectance measurements, and scanning electron microscopy, the phase transformation of NMP solvate into SD was tracked. Higher temperatures and stirring rates accelerate the transformation process and have a negative influence on the final SD product quality.