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Influence of Solvents on Solution‐Mediated Polymorphic Transformation of the Polymorphs of L ‐Histidine
Author(s) -
Wantha Lek,
Punmalee Neeranuch,
Flood Adrian E.
Publication year - 2019
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201800699
Subject(s) - crystallization , metastability , volume fraction , acetonitrile , polymorphism (computer science) , methanol , raman spectroscopy , crystallography , mole fraction , chemistry , phase (matter) , supersaturation , fraction (chemistry) , acetone , transformation (genetics) , materials science , chromatography , organic chemistry , biochemistry , physics , genotype , optics , gene
Solution‐mediated polymorphic transformation (SMPT) of the metastable polymorph B of L ‐histidine ( L ‐his) into the stable polymorph A in water‐antisolvent solutions was performed. Methanol, acetone, and acetonitrile served as antisolvents. The SMPT was studied via nucleated batch antisolvent crystallization process by determining the change of the fraction of the stable polymorph A of L ‐his in the crystal phase with time during the crystallization process. The fraction of the stable polymorph A of L ‐his was assessed offline by Raman spectroscopy. The transformation time depended on the fractions of form A obtained at the initial stage of crystallization. The transformation rate of the metastable polymorph B into the stable polymorph A at lower antisolvent volume fraction was faster than at higher antisolvent volume fraction. The transformation time of polymorph B into polymorph A in water‐acetonitrile solution was the shortest compared to the other solutions.