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Growth Rate Measurements of Organic Crystals in a Cone‐Shaped Fluidized‐Bed Cell
Author(s) -
Ostermann Marie-Christine,
Termühlen Maren,
Schembecker Gerhard,
Wohlgemuth Kerstin
Publication year - 2018
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201700683
Subject(s) - supersaturation , factorial experiment , growth rate , fluidized bed , saturation (graph theory) , crystal growth , yield (engineering) , materials science , crystal (programming language) , chemistry , process engineering , chemical engineering , crystallography , mathematics , engineering , composite material , computer science , organic chemistry , statistics , geometry , combinatorics , programming language
Knowledge of crystal growth rates and the factors that affect these rates is often an essential prerequisite for designing industrial processes that yield a desired crystalline product. Herein, the effects of saturation temperature, supersaturation, and seed‐crystal size on the overall linear growth rate of L ‐alanine were examined by using a cone‐shaped fluidized‐bed cell. For a systematic investigation, a “design of experiment” approach was applied that used a two‐level full‐factorial design. It was found that the interaction effects of the three factors mentioned above play a considerable role in interpreting the effect of each individual factor on the growth rate. These interaction effects must be considered when gaining knowledge of crystal growth for the purpose of process design.