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Particle Size Distributions and Performance of Preferential Crystallization of L‐ Asparagine·H 2 O with Tailor‐Made Additives
Author(s) -
Kongsamai Peetikamol,
Flood Chalongsri,
Horst Joop H.,
Flood Adrian E.
Publication year - 2018
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201700668
Subject(s) - crystallization , yield (engineering) , enantiomer , particle size , chemistry , crystal (programming language) , aspartic acid , nuclear chemistry , crystallography , materials science , chemical engineering , stereochemistry , organic chemistry , amino acid , biochemistry , metallurgy , computer science , engineering , programming language
Preferential crystallization (PC) is a process to separate enantiomers. The efficiency of seeded, isothermal PC was enhanced using tailor‐made additives to inhibit the crystallization of the counter‐enantiomer. The inhibition of D‐ asparagine ( D‐ Asn) monohydrate using D‐ glutamic acid ( D‐ Glu) and D‐ aspartic acid ( D‐ Asp) as additives in PC was investigated by comparing the purity, yield, and particle size distribution after PC of L‐ Asn·H 2 O from DL‐ Asn·H 2 O. The amount of pure L‐ Asn·H 2 O solid product that can be produced before crystallization of the counter‐enantiomer is higher when using the additives D‐ Asp and D‐ Glu. However, the crystal size of L‐ Asn·H 2 O increases faster in PC without additives than in PC with additives. This means that the additives inhibit not only the crystallization of D‐ Asn·H 2 O but also the crystal growth of L‐ Asn·H 2 O.