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Co‐Crystal of Paracetamol and Trimethylglycine Prepared by a Supercritical CO 2 Anti‐Solvent Process
Author(s) -
Zhao Ziyi,
Liu Guijin,
Lin Qing,
Jiang Yanbin
Publication year - 2018
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201700638
Subject(s) - supercritical fluid , tableting , dissolution , solubility , solvent , materials science , particle size , ball mill , chemical engineering , crystal (programming language) , particle (ecology) , ultimate tensile strength , chemistry , crystallography , analytical chemistry (journal) , chromatography , composite material , organic chemistry , oceanography , computer science , engineering , programming language , geology
Paracetamol (PCA) and trimethylglycine (TMG) were co‐crystallized and micronized by means of the supercritical anti‐solvent (SAS) process to improve the tabletability of PCA. The effects of operating conditions on particle properties were investigated in detail. Characterizations were performed to confirm the co‐crystal state of PCA‐TMG. The results indicated that the same crystal form with different crystal habits was prepared. The optimal PCA‐TMG co‐crystals presented a much larger tensile strength, higher drug content of PCA, and smaller particle size than those obtained using the ball milling (BM) process. The SAS‐processed PCA‐TMG co‐crystals showed an enhanced solubility, dissolution rate, and tableting performance compared to that of BM.