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Advanced Operating Strategies to Extend the Applications of Simulated Moving Bed Chromatography
Author(s) -
Kim Kyung-Min,
Lee Ju Weon,
Kim Sunhee,
Santos da Silva Francisco Vitor,
Seidel-Morgenstern Andreas,
Lee Chang-Ha
Publication year - 2017
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201700206
Subject(s) - simulated moving bed , countercurrent exchange , process engineering , chromatography , process (computing) , column chromatography , chemistry , computer science , engineering , adsorption , organic chemistry , physics , thermodynamics , operating system
Chromatographic separation with solid stationary and fluid mobile phases is widely used to isolate and purify compounds. One of the most productive improvements in preparative chromatography is the simulated moving bed (SMB) process, which enables continuous feed supply and product removal by periodic operation of a multicolumn to simulate a countercurrent flow between the phases. The SMB process produces high‐purity compounds, even with low selectivity, and offers higher productivity and lower eluent consumption than batch chromatography. Recently, intensive efforts have been made to expand the range of applications through the design, modeling, and optimization of the SMB process to produce advanced operating strategies, which are described and evaluated in this review.