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Comparing the Dynamic Flow Properties and Compaction Properties of Pharmaceutical Powder Mixtures
Author(s) -
Leaper Mark C.,
Ali Kashaf,
Ingham Andrew J.
Publication year - 2018
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201600651
Subject(s) - excipient , compaction , mannitol , flow properties , rheometer , materials science , ingredient , sodium carbonate , active ingredient , rheology , chromatography , chemical engineering , chemistry , sodium , composite material , organic chemistry , metallurgy , engineering , physics , mechanics , bioinformatics , food science , biology
The dynamic flow properties and compaction characteristics of mannitol and mannitol‐sodium carbonate mixtures were measured using a Freeman FT4 powder rheometer. The results showed that the mixtures containing up to 30 % sodium carbonate had better flow properties and improved compaction characteristics when compared with mannitol alone. The mixtures were also analyzed using a shear cell, which gave flow functions that varied little between the samples. The feasibility of combining a more expensive pharmaceutical excipient with a cheaper ingredient is demonstrated, without compromising desired powder characteristics. The study may also provide a useful method for assessing the suitability of new formulations for application as direct compression bases, as part of a wider range of powder flow tests.