Comparing the Dynamic Flow Properties and Compaction Properties of Pharmaceutical Powder Mixtures | Zendy

Leaper Mark C. | Zendy; Ali Kashaf | Zendy; Ingham Andrew J. | Zendy

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Comparing the Dynamic Flow Properties and Compaction Properties of Pharmaceutical Powder Mixtures

Author(s) -

Leaper Mark C.,

Ali Kashaf,

Ingham Andrew J.

Publication year - 2018

Publication title -

chemical engineering and technology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.403

H-Index - 81

eISSN - 1521-4125

pISSN - 0930-7516

DOI - 10.1002/ceat.201600651

Subject(s) - excipient , compaction , mannitol , flow properties , rheometer , materials science , ingredient , sodium carbonate , active ingredient , rheology , chromatography , chemical engineering , chemistry , sodium , composite material , organic chemistry , metallurgy , engineering , physics , mechanics , bioinformatics , food science , biology

The dynamic flow properties and compaction characteristics of mannitol and mannitol‐sodium carbonate mixtures were measured using a Freeman FT4 powder rheometer. The results showed that the mixtures containing up to 30 % sodium carbonate had better flow properties and improved compaction characteristics when compared with mannitol alone. The mixtures were also analyzed using a shear cell, which gave flow functions that varied little between the samples. The feasibility of combining a more expensive pharmaceutical excipient with a cheaper ingredient is demonstrated, without compromising desired powder characteristics. The study may also provide a useful method for assessing the suitability of new formulations for application as direct compression bases, as part of a wider range of powder flow tests.

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