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Optimizing the Crystal Habit of Glycine by Using an Additive for Impinging Jet Crystallization
Author(s) -
Tari Tímea,
Ambrus Rita,
Szakonyi Gerda,
Madarász Dániel,
Frohberg Patrick,
Csóka Ildikó,
Szabó-Révész Piroska,
Ulrich Joachim,
Aigner Zoltán
Publication year - 2017
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201600634
Subject(s) - crystallization , differential scanning calorimetry , crystal habit , scanning electron microscope , crystal (programming language) , solvent , chemistry , potassium , analytical chemistry (journal) , particle size , crystal growth , crystallography , materials science , chromatography , chemical engineering , organic chemistry , physics , computer science , thermodynamics , programming language , engineering , composite material
Additives selectively inhibit or enhance the growth of crystal faces and effectively change the crystal morphology. For the first time, potassium chloride was used as additive during impinging jet crystallization of glycine. The structure of the powder particles was evaluated by X‐ray powder diffraction, differential scanning calorimetry, scanning electron microscopy with energy dispersive X‐ray spectroscopy, headspace gas chromatography, and flame atomic absorption spectrometry. Even a minor amount of KCl had a significant effect on the crystal roundness and reduced the particle size significantly, despite of the extremely rapid nature of the crystallization process. This method resulted in the α ‐polymorph of glycine with an appropriate low residual additive content and a minimal residual organic solvent content. The arrangement and the optimal concentration of the additive were determined.