Premium
Opening of New Synthetic Routes Using Segmented Microflow in Multistep Syntheses
Author(s) -
Karl Dominik,
Börner Pia,
Misuk Viktor,
Löwe Holger
Publication year - 2017
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201600367
Subject(s) - flow chemistry , microfluidics , biochemical engineering , chemistry , combinatorial chemistry , organic synthesis , nanotechnology , continuous flow , reaction conditions , field (mathematics) , process engineering , computer science , organic chemistry , materials science , engineering , catalysis , mathematics , pure mathematics
The application of microfluidics in organic chemistry is a valuable tool to access new synthesis pathways and to break limitations set by traditional batch chemistry. In the past, the majority of research focused on solving problems associated with individual reactions. It is necessary to advance the field by incorporating flow chemistry in longer multistep syntheses to open more direct paths towards complicated compounds. Several strategies were developed to meet the demands of a four‐step synthesis, which includes biphasic nitrations, gaseous substrates, and very fast reactions on multifunctional molecules. A unique micro flow setup was applied in each reaction to meet its specific requirements.