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Design of a Continuous Tubular Cooling Crystallizer for Process Development on Lab‐Scale
Author(s) -
Hohmann Lukas,
Gorny Ramona,
Klaas Oliver,
Ahlert Jonas,
Wohlgemuth Kerstin,
Kockmann Norbert
Publication year - 2016
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201600072
Subject(s) - crystallization , process engineering , residence time distribution , plug flow , scale up , water cooling , materials science , nucleation , process (computing) , mechanical engineering , chemical engineering , flow (mathematics) , chemistry , thermodynamics , engineering , mechanics , computer science , physics , classical mechanics , operating system
Continuous manufacturing of fine chemical, life science, and pharmaceutical products is under recent investigation in R&D. As cooling crystallization is an important unit operation for purification of products, continuously operated, scalable devices are required for process development on lab‐scale. A tubular crystallizer was developed, based on the coiled flow inverter design. Experimental characterization proved a narrow residence time distribution of the liquid phase close to ideal plug flow. Counter‐current air cooling allows for adjusting linear and curved temperature profiles. Unseeded operation with the L ‐alanine (water) system demonstrated that nucleation has to be actively controlled to successfully apply intensified continuous cooling crystallization processes.