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Supramolecular Reaggregation of Acetyl Salicylic Acid‐4,4′Dipyridyl Cocrystals from Salicylic Acid‐4,4′Dipyridyl Cocrystals
Author(s) -
Lee KyeongSill,
Kim KwangJoo,
Ulrich Joachim
Publication year - 2016
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201600042
Subject(s) - cocrystal , salicylic acid , chemistry , supramolecular chemistry , mechanochemistry , hydrogen bond , molecule , organic chemistry , combinatorial chemistry , biochemistry
Screening of the change mechanism of salicylic acid‐4,4′dipyridyl (SAA‐4,4′dipy) cocrystals to acetyl salicylic acid‐4,4′dipyridyl (ASA‐4,4′dipy) cocrystals was performed and their transformation investigated. Cocrystals of SAA‐4,4′dipy are concomitantly formed in ASA/4,4′dipyridyl/ethanol solutions, resulting from ASA decomposition. Eventually, cocrystals of ASA‐4,4′dipy are obtained from a sequence of in situ reactions by controlling the operating conditions. Both cocrystals have the same hydrogen bonding interaction between the drug molecules. The ketene functional group decomposed in salicylic acid cocrystal formation reaggregates during solution‐mediated cocrystallization that leads to the formation of ASA cocrystals.