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Partial Blockage of the Reversible Solid‐Solid Transition of Strontium Succinate
Author(s) -
Couvrat Nicolas,
Martins Damien,
Lafontaine Anaïs,
Sanselme Morgane,
Dupray Valérie,
Taulelle Pascal,
Lerestif JeanMichel,
Lynch Michael,
VaysseLudot Lucile,
Coquerel Gérard
Publication year - 2016
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201500726
Subject(s) - crystallization , mosaicity , raman spectroscopy , strontium , thermogravimetric analysis , materials science , chemical engineering , diffraction , crystallography , x ray crystallography , chemistry , organic chemistry , physics , optics , engineering
Strontium succinate, an active pharmaceutical ingredient against osteoporosis, exhibits two polymorphs related by a reversible order‐disorder transformation at about 50 °C. However, during the industrial crystallization process, the transition from the high‐temperature form towards the low‐temperature form was partially inhibited, leading to a mixture of phases at room temperature. The stressful character of the industrial process as demonstrated by in situ X‐ray diffraction and Raman analyses led to defects, constraints, and a coarse mosaicity within crystals. Moreover, thermogravimetric analyses revealed that a non‐negligible amount of water was trapped inside the crystalline solid. The combination of these two factors (stressful crystallization and trapped water) could be at the origin of the partial blockage of the transition.