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Bioproduction of Floxuridine Using Nanostabilized Biocatalysts
Author(s) -
Cappa Valeria A.,
Rivero Cintia W.,
Sambeth Jorge E.,
Trelles Jorge A.
Publication year - 2016
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201500522
Subject(s) - bioproduction , floxuridine , bioprocess , chemistry , biocompatibility , biocatalysis , bentonite , chemical engineering , chromatography , organic chemistry , catalysis , biochemistry , reaction mechanism , medicine , fluorouracil , surgery , chemotherapy , engineering
Bionanocomposites employing natural polysaccharides such as alginate and nanoclays, e.g., bentonite, are a promising alternative to developing stabilized biocatalysts used in the pharmaceutical industry due to their physicochemical properties, biocompatibility, and nontoxicity. Mechanical parameters such as swelling ratio, compressive strength, and fracture frequency were optimized, favoring scale‐up. Moreover, storage stability and reusability of the biocatalysts were improved by more than 90 % compared with control conditions. In addition, immobilized lactic acid bacteria were used in the bioprocess scale‐up to obtain floxuridine, showing a high productivity per gram of biocatalyst.