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A Short Multistep Flow Synthesis of a Potential Spirocyclic Fragrance Component
Author(s) -
Baxendale Ian R.
Publication year - 2015
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201500255
Subject(s) - flow chemistry , context (archaeology) , component (thermodynamics) , biochemical engineering , computer science , key (lock) , process (computing) , chemistry , combinatorial chemistry , chemical synthesis , process engineering , continuous flow , engineering , programming language , paleontology , biochemistry , physics , computer security , in vitro , biology , thermodynamics
The search for novel chemical architectures displaying improved biological properties is a never‐ending synthetic challenge. In this context many new test structures are often conceived by selecting and replicating specific design elements from naturally occurring molecules and displaying them in an alternative format by way of a new chemical assembly. Constructing these newly designed compounds can be a timely and expensive process especially when a large quantity of the target material is required for physiochemical and property testing. To permit easier scale‐up and safer working practice, many chemical researchers are employing flow chemistry approaches to aid in their synthesis challenges. The preparation of a key spirocyclic lactone using flow‐based reaction processing techniques is reported.