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Photochemical Fluorination Reactions – A Promising Research Field for Continuous‐Flow Synthesis
Author(s) -
Rehm Thomas H.
Publication year - 2016
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201500195
Subject(s) - microreactor , fluorine , reagent , chemistry , catalysis , flow chemistry , continuous flow , electronegativity , selectivity , halogenation , nanotechnology , photochemistry , organic chemistry , combinatorial chemistry , materials science , biochemical engineering , engineering
The unique properties of fluorine resulting from its tremendously high electronegativity make it a key player in the quest of enabling new and advanced qualities for chemical compounds and materials. With the advent of fluorinating reagents, a great diversity of synthetic methodologies has been developed to incorporate fluorine or fluorine‐containing groups into small molecules with high conversion and selectivity. Especially photochemically catalyzed fluorination reactions proved their potential for the synthesis of fluorine‐containing fine chemicals due to their mild reaction conditions. This tutorial review gives an overview of recently published synthesis strategies that use (visible‐) light‐absorbing catalysts for the activation of fluorinating reagents. A special focus lies on the use of continuous‐flow microreactors for photochemically catalyzed fluorination reactions due to the excellent utilization of this reactor equipment for photochemistry.