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Microflow SERS Measurements Using Sensing Particles of Polyacrylamide/Silver Composite Materials
Author(s) -
Visaveliya* Nikunjkumar,
Lenke* Steffen,
Groß Alexander,
Köhler J. Michael
Publication year - 2015
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201500035
Subject(s) - analyte , microfluidics , materials science , spectrometer , raman scattering , capillary action , nanotechnology , nanoparticle , composite number , matrix (chemical analysis) , detection limit , analytical chemistry (journal) , raman spectroscopy , chromatography , chemistry , optics , composite material , physics
The combination of microfluidic techniques with surface‐enhanced Raman scattering (SERS) microscopy provides the platform for the analysis, detection, and accurate monitoring of a wide range of analytes. Composite microparticles for SERS sensing were used here for the detection of analytes in a micro‐continuous‐flow arrangement. The sensor particles consisted of a swellable polyacrylamide matrix with in situ incorporated silver nanoparticles. They were prepared by a microfluidic photochemical procedure. A set of sensor particles was placed inside a glass capillary for SERS flow measurements. Highly reproducible sensor signals were observed with the test analytes adenine and histidine using a fiber‐coupled compact Raman spectrometer. The particles are suited for sequential measurements under flow conditions. This could be proven by the use of a microfluidic setup with three syringe pumps for alternative actuation of different analyte and regeneration solutions.