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Process Intensification Tools in the Small‐Scale Pharmaceutical Manufacturing of Small Molecules
Author(s) -
Mitic Aleksandar,
Gernaey Krist V.
Publication year - 2015
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201400765
Subject(s) - process engineering , microreactor , process (computing) , pharmaceutical industry , scale (ratio) , slurry , pharmaceutical manufacturing , scale up , biochemical engineering , sustainability , chemical process , process development , productivity , chemical industry , nanotechnology , environmental science , manufacturing engineering , computer science , chemistry , materials science , engineering , chemical engineering , catalysis , environmental engineering , microbiology and biotechnology , organic chemistry , macroeconomics , ecology , biology , operating system , classical mechanics , quantum mechanics , bioinformatics , physics , economics
The chemical process industry is paying significant attention to the intensification of processes with the main aim of achieving increased productivity, improved economic status, and enhanced sustainability. The pharmaceutical industry is moving in the same direction and, therefore, dozens of processes are in a state of change. However, it is important to note that not all processes can be intensified easily, such as slow chemical reactions, processes with solids, slurries, and on the like. This review summarizes applications of promising tools for achieving process intensification in the small‐scale pharmaceutical manufacturing of so‐called small molecules. The focus is on microwave radiation, microreactors, ultrasounds, and meso‐scale tubular reactors.